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How ROSE-010 Works in IBS: Targeted, On-Demand Pain Relief ROSE-010 mimics natural GLP-1 with an optimized, short-acting profile: Fast-acting ( Begins working in 20 minutes ) Short duration ( Clears in a few hours ) Use only when needed during acute episodes for pain resolution Clinical Validation: Proven IBS Pain Relief In Phase 2a Trial Results (Hellstrm et al.), ROSE-010 166 patients with IBS pain (placebo-controlled study) Twice as many patients responded to ROSE-010 vs

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However, species differences limit direct extrapolation

According to the Cleland nomenclature the reaction should follow a uni-uni-bi-uni ping-pong mechanism 8,59 , although detailed kinetic studies to confirm the mechanism for EcGrx1 or the F

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