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What excites me is that 22.6% in Class 2/3 obesity with established cardiovascular disease is a remarkable number for a population that has historically had one route to that magnitude of loss, and that route involved an operating theatre

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FIGURE 7 Discussion Glucagon-like peptide 1, a peptide hormone from the intestinal tract, plays a central role in the coordination of postprandial glucose homeostasis ( Glucagon-like peptide 1 exerts its physiological function by binding to a dedicated G-protein-coupled receptor, GLP-1R, expressed in a variety of cell types ( via the vagal and/or endocrine pathways) remains controversial, and the necessary intestine-brain circuit has not been empirically confirmed ( Glucagon-like peptide 1 forms the basis for a variety of current drugs for the treatment of type 2 diabetes and obesity, as well as new agents currently being developed

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