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Neurotrophins such as BDNF and NGF play central roles in synaptic plasticity, neuronal survival, and network organization, and their dysregulation may represent a more proximal mechanism underlying behavioral impairments

doi: 10.3390/cosmetics11050148

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3.4.6 TAM family of receptor tyrosine kinases The increase in CORT induced by stress also activates the GR-MERTK signaling pathway in astrocytes, leading to heightened phagocytosis of excitatory synapses by astrocytes in cortical regions, thereby eliciting depressive behavior in mice (255)

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In microglia, TREM2 is responsible for synaptic inhibition and establishing normal brain connections, maintaining innate immune homeostasis and cellular metabolism (186)