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Wang, T.C

Most patients have none beyond mild tingling, slight redness, or a little dryness in the first week, and that usually settles as your skin adjusts

Prolonged high doses may reduce zinc levels, as glutathione influences metal ion balance in the body

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But the same 2025 review that catalogs those effects also underscores that only three human clinical trials have been published and that the compound remains investigational, with regulators having flagged it precisely because human safety and efficacy are not established