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Potential and theoretical risks include the following: Neuroendocrine effects: because DSIP can influence hormone secretion and the stress axis, unsupervised use could theoretically disrupt these systems in unpredictable ways

It is especially important for high-energy organs like the heart and muscles

Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men

Vitamin B12 toxicity from supplements is extremely rare because it is water-soluble and excess amounts are excreted through urine

Acne vulgaris: A small 2012 clinical trial with three subjects reports that MT-I may help reduce inflammation in acne lesions

Large-scale observational data adds another layer