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Additional research considerations include characterizing whether the enhanced membrane permeability of the acetylated form alters tissue distribution in in vivo models, whether the modified charge distribution affects receptor or chromatin binding dynamics, and whether the extended half-life requires adjusted concentration protocols in cell culture systems

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P-selectin tethers (captures) free-flowing neutrophils to the surface of endothelial cells by binding to P-selectin glycoprotein ligand 1 (PSGL1), subsequently rolling along blood vessels in the direction of blood flow 112 (Fig