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Collagen is a structural protein primarily focused on replenishing the structural framework of the skin, leading to improved elasticity and reduction of deep wrinkles

DOI: 10.1016/j.jacc.2017.03.003

The accelerating effect of histamine on the cutaneous wound-healing process through the action of basic fibroblast growth factor

These havent been performed, though, perhaps because of this treatments downsides IV glutathione can be expensive, inconvenient and associated with potential side effects (bleeding, infection, blood clots, etc.)

Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug

Combine them, and you get synergistic effects that exceed what either approach achieves independently