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1,961 participants with BMI of 30+ (or 27+ with at least one weight-related condition) received either semaglutide 2.4 mg or placebo weekly for 68 weeks, alongside lifestyle intervention

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In cases where adherence may be an issue, or where dose adjustments may be necessary, AZA or 6MP metabolites may be measured in red blood cells by specialized testing

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Figure 5 shows results for the citric acid cycle, in which 8 enzymes were upregulated within this dataset, including aconitase, the rate-limiting isocitrate dehydrogenase, succinyl CoA synthetase, fumarase, and malate dehydrogenase