Although inflammation can be a protective response, sustained activation of neuroinflammatory pathways leads to neuronal injury and causes the progression of neurodegenerative disorders ( 2.5 Impaired protein degradation systems Dysfunction in systems responsible for protein degradation, such as the ubiquitin-proteasome system (UPS) and autophagy, contributes to the development of AD and PD
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Pratley RE, Crowley MJ, Gislum M, et al
It would require stopping tirzepatide and even then, the relief would likely be temporary, with repeat procedures potentially needed down the line
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