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They also contain the same active ingredient, semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist
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de Lemos has received honoraria for chairing the Data Safety and Monitoring Board for the SURMOUNT-1 trial
However, its clinical application is limited by its undetermined toxicity and side effects [15]
Until we better understand their action on the brain, its far too soon to call GLP-1 and GIP inhibitors miracle drugs for more conditions beyond type 2 diabetes and obesity. Even without the diagnosis of BED, up to 60% of people with obesity report experiencing food noise or thinking about food constantly which leads to distress and dysregulated eating behaviors, like loss of control eating and binge eating
2014;306:E13781387
