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Mouse hippocampal cells were subsequently scored on the activity of these two gene sets using the Seurat function AddModuleScore

They both play important roles in lowering inflammation, maintaining metabolism, and balancing hormones and blood sugar

(PubMed) Ji HF

Phase 2 data published in The New England Journal of Medicine in 2023 suggest meaningful weight reductions can begin within the first few months of treatment, with results continuing to build over 48 weeks