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Except for the GPX1 gene, branches subjected to positive selection were detected in six other genes, in which the number of positively selected sites accounted for 89% of the hypoxia-tolerant branches/species (Figure 1, Supplementary Table S5)

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In the investigation of KRAS/LKB1/KEAP1 mutant lung adenocarcinoma cells, mild oxidative stress was observed to decrease NRF2 SUMOylation, which in turn enhanced the migration and invasion of these cells [132]

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