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Trends & Treatment Insights for 2025 Real-world data show rapid adoption in type 2 diabetes care: between early 2022 and mid-2024, roughly 1 in 5 type 2 diabetes patients were on GLP-1 therapy

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However, the following groups should exercise particular caution and seek medical advice before use: Individuals with chronic kidney disease (CKD) or a history of renal impairment, as creatine increases creatinine excretion and may complicate renal monitoring Pregnant or breastfeeding individuals , due to insufficient safety data People taking nephrotoxic medications or other supplements that affect renal function Note: creatine is not hepatically metabolised in the conventional sense, and routine caution in liver disease is not well established

Caffeine can also prompt hypoglycemia, or low blood sugar, which can also increase appetite and cause the body to crave higher calorie foods