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The timing of these symptoms is important: nausea and digestive issues are most pronounced during the initial weeks of treatment and following dose escalations

However, Wegovy and similar drugs are being introduced at a rapid rate, since they are much more effective than earlier obesity treatments

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Think of it like a thermostat that was set at 72 degrees for months, then you turn it down

This temperature sensitivity is characteristic of peptide therapeutics and necessitates careful handling throughout the medication's lifecycle

The expression of pre-proglucagon gene and GLP-1 has been detected in the human brainstem and hypothalamus (140)