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We applied this strategy only to PM- and Golgi-localized zDHHCs but we expect it will also work for the remaining PATs, excluding zDHHC24 with a predicted C-terminus facing the lumen 38

A recent investigation of its mechanism of action showed that AcM does not exhibit direct antimicrobial activity as it does not target the PGN of live bacteria but rather luminal cell-free PGN fragments, whilst it is able to promote anti-inflammatory pathways through nucleotide-binding oligomerization domain-containing protein 2 receptor activation [24]

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