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AAV-mediated shRNA interference of nodose ganglion in rats The left NG of male Wistar rats was surgically exposed under anesthesia (Tribromoethanol 200 mg kg 1 i.p.)

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Over a median follow-up time of 21.4 years, 603 participants developed cardiovascular disease, 362 developed diabetes, and 843 participants passed away

Neuropediatrics 27:115123 Kolker S, Christensen E, Leonard JV, Greenberg CR, Boneh A, Burlina AB, Burlina AP, Dixon M, Duran M, Garcia Cazorla A, Goodman SI, Koeller DM, Kyllerman M, Muhlhausen C, Muller E, Okun JG, Wilcken B, Hoffmann GF, Burgard P (2011) Diagnosis and management of glutaric aciduria type Irevised recommendations

Any P value passing this significance (and correction) threshold is in bold text in the tables

Beyond weight reduction alone, these trials have also shown improvements across a range of cardiometabolic markers, including blood pressure, lipid profiles, glycemic control, and inflammatory measures