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Lancet Diabetes Endocrinol, 2018
Although this study is based on real-world data in a representative population of people with type 2 diabetes, enhancing its external validity, the improvements in HbA 1c seen after introduction of tirzepatide were modest in comparison with those seen in clinical trials and may not be applicable in a population with less-optimised baseline glycaemic control
Youll stop at the dose that is effectively controlling your blood sugar
Go over the patients medication history, specifically the timing of GLP-1 agonist
Furthermore, in a mouse model of amyloid pathology, AAV-mediated human ApoE gene expression revealed that the presence of the ApoE4 allele exacerbated synaptic loss and A deposition, while the ApoE2 allele expression in the same model led to a reduction in brain A levels (Yamazaki et al., 2019
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