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H., & Wilding, J

NNMT is an enzyme that converts nicotinamide to N-methylnicotinamide, consuming methyl groups and potentially reducing NAD+ availability

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It is involved in reducing reactive oxygen species and reactive nitrogen species, which are compounds that increase during times of infection and stress

5-Amino-1MQ binds the NNMT active site at low micromolar Ki, producing selective inhibition relative to other SAM-dependent methyltransferases [1]