Common: nausea (especially during dose increasesusually mild and transient), constipation or diarrhea, occasional vomiting, fatigue in first weeks, decreased appetite (the desired effect, but worth noting)
Retatrutide mimics three hormones (GIP, GLP-1, and glucagon) to increase satiety, slow digestion, and boost metabolism
& McCarty, D
Side effects may increase with this jump, particularly nausea during the first few days after each injection
But the 9% one-star rate deserves attention, because those reviews reveal the failure modes that happy customers never encounter
We recommend using insulin syringes with 29G-31G needles for general comfort during the procedure