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The role vitamin B12 plays in the production of myelin, the substance that forms the protective sheath around the nerve fibers, might be the most significant of vitamin B12s many health advantages from the perspective of nerve health

Therefore, with carbidopa around, the enzyme that converts levodopa into dopamine does not work as well and less levodopa is converted into dopamine in the bloodstream and more makes it into the brain

However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels

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PMID 18606874