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The two models were employed to address the limitations of the Fine-Gray model, which does not adequately incorporate the TDC, and the Cox model, which does not account for competing risks
Most practitioners recommend starting at 250-300 mcg daily to assess tolerance, then potentially increasing to 400-500 mcg if initial response is suboptimal and no side effects occur
[5] Work on tissue-specific targeting and metabolic stability continues in research settings
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