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Specific situations warranting medical advice include: Persistent nausea or vomiting that prevents adequate food or fluid intake, potentially leading to dehydration Severe abdominal pain , particularly if accompanied by fever, as this may indicate pancreatitisa rare but serious adverse effect of GLP-1 receptor agonists [1] [2] Unexplained weight loss plateau or weight regain despite adherence to the medication, which may indicate the need for dietary review or dose optimisation Signs of gallbladder disease , such as persistent right upper quadrant pain, fever, or jaundice, as rapid weight loss can increase the risk of gallstones [15] Difficulty maintaining adequate nutrition due to excessive appetite suppression or food aversions Seek urgent medical attention via NHS 111, urgent care, or A&E for severe or worsening upper abdominal pain (especially with vomiting), persistent vomiting, or signs of dehydration

In the liver, BPC 157 reduced congestion and severe sinusoid enlargement

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While many patients tolerate fasting well on GLP-1s, others may need to adjust their fasting window, meal composition, or activity level depending on how their body responds to both