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In December 2025, Eli Lilly announced positive topline results from TRIUMPH-4 a 68-week Phase 3 trial in adults with obesity and knee osteoarthritis in which retatrutide delivered average weight loss of up to 71.2 lbs alongside substantial reductions in osteoarthritis pain

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Schommers et al., 2017) and modified the expression of genes related to mitochondria (Yang et al., 2021), potentially leading to a rise in anaerobic glucose metabolism

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