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Kidney and cardiovascular outcomes SURPASS-4 kidney composite HR 0.58, slower eGFR decline (-1.4 vs -3.6 mL/min/1.73m2/yr), UACR -6.8% vs +36.9%

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For Wegovy (semaglutide 2.4 mg for weight management), the STEP clinical trials reported headaches in approximately 14% of patients receiving the medication compared to about 10% in the placebo group

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However, it is possible that participants receiving L-Carnitine-combination or L-Carnitine may show improvements in these measures over a longer supplementation period

GLP-1 medications may cause side effects including nausea, vomiting, diarrhea, constipation, and abdominal pain