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The supernatant was discarded and samples were resuspended in 5 Laemmli buffer
However, futile quinone redox cycling can lead to a cascade of ROS formation and as such, the link between toxicity and quinone redox cycling is widely acknowledged 5
A Phase 2 trial evaluating doses as low as 1 mg demonstrated measurable improvements in HbA1c levels and body weight, with fewer gastrointestinal side effects compared to higher doses, suggesting that starting with microdoses may enhance tolerability
Sanyal, L
Nampoothiri S, Nogueiras R, Schwaninger M, Prevot V
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