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Decreased leptin levels during weight loss may signal the body to conserve energy, potentially affecting thermogenesis
Second, tirzepatide has more granularity
For optimal results, tirzepatide should be combined with healthy lifestyle changes
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Medical history, contraindications, financial capacity, adherence capacity, and personal preferences all factor into treatment selection, which should be made in consultation with licensed clinicians
Am J Manag Care
Yet most of the data we quote on weight regain after GLP-1s come from trials that studied drug withdrawal, not deprescribing
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