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Oxidative stress induces ER stress and UPR in LECs under high-sugar conditions, resulting in increased ROS formation and apoptosis 44
The ACOT4 encoded enzyme possesses a type I peroxisomal targeting sequence and exhibits substrate specificity for short-chain dicarboxylic acyl-CoA esters, particularly succinyl-CoA, and medium- to long-chain acyl-CoAs
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