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Repeatedly applying patches to the same location can cause contact dermatitis, skin sensitization, or localized tissue changes that impair drug absorption
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions
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Kariya C, Chu HW, Huang J, Leitner H, Martin RJ, Day BJ: Mycoplasma pneumoniae infection and environmental tobacco smoke inhibit lung glutathione adaptive responses and increase oxidative stress
Individual responses vary significantly based on baseline cardiovascular fitness, existing heart conditions, and genetic factors
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