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ZDHHC7 and APT2 promote the formation and nuclear translocation of the SMAD2-STAT3-SMAD4 complex by regulating the palmitoylation-depalmitoylation dynamic balance of SMAD2 and STAT3, thereby driving the differentiation of naive T cells into Th17 cells

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Recent FDA approvals have expanded the indication for semaglutide to include the reduction of major adverse cardiovascular events (MACE), such as heart attack, stroke, and cardiovascular death, in adults with established cardiovascular disease and obesity