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5A-1MQ-treated mice switched from WD to LD (WD/LD-T) showed a rather reduced relative abundance of Akkermansia compared to vehicle-treated DIO animals switched from WD to LD (WD/LD-V), suggesting a unique microbiome mechanism associated with weight loss in the vehicle-treated group switched from WD to LD compared to the 5A-1MQ-treated group that underwent the same diet switch
This is a compound that is sort of like a hormetic compound, or as David Sinclair likes to say, it's a xenohormetic compound
B12 is a cofactor for succinyl-CoA synthesis and for the conversion of homocysteine to methionine
P = .01
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