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It is not a DEA-scheduled controlled substance

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274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)

doi: 10.1038/nm.4068 16 BercikP.DenouE.CollinsJ.JacksonW.LuJ.JuryJ.et al

Inhibitory effect of berberine hydrochloride against Candida albicans and the role of the HOG-MAPK pathway