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LC-MS/MS studies developed assays and confirmed detectability of metabolites in horse plasma/urine after administrationuseful as hard evidence of veterinary use, albeit in a doping-control context rather than therapy

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It was first isolated from human plasma, where it naturally occurs at concentrations of around 200 ng/mL at age 20, declining to approximately 80 ng/mL by age 60

Among patients with ALD, female patients and patients on public insurance experience even more pronounced barriers to transplant waitlisting