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Scientific References TripleHormone-Receptor Agonist Retatrutide for Obesity (Jastreboff et al.)

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Simultaneously, Akt activation suppresses the ubiquitin proteasome system through inhibition of FoxO-mediated transcription of E3 ubiquitin ligases (MAFbx/Atrogin-1, MuRF1), which are responsible for protein degradation