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Rapid weight loss from taking GLP-1 medications like Ozempic and Wegovy can cause a decrease in muscle mass, lessen bone density, and lower your resting metabolic rate, leading to sarcopenia
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Common side effects include nausea, fatigue, hot flashes, rashes, and insomnia (trouble sleeping), which can be uncomfortable
In trials of other GLP-1 medications, people who stopped suddenly without having built supporting habits regained much of the weight, so we recommend building habits during treatment and reducing the dose gradually rather than stopping abruptly
Chi J, Shu J, Li M, Mudappathi R, Jin Y, Lewis F, et al
Berberine AMPK activation, insulin sensitization, and lipid-modulating effects may provide a degree of metabolic stability during the transition off tirzepatide that helps prevent full metabolic rebound
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