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Beyond AMPK activation, MOTS-c translocates to the nucleus under conditions of metabolic stress, where it interacts with the antioxidant response element pathway and modulates gene expression related to reactive oxygen species management
Scientists are exploring its relevance in weight and metabolic research
Shiraz E-Medical Journal, 15 (4)
Am J Physiol Endocrinol Metab 2012;303:E253-64.ArticlePubMed 72
In addition, it can be converted to its extremely toxic metabolite NAPQI by the cytochrome P450 (CYP)2E1 enzyme
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