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Human studies vary in design, but several themes repeat

For example, epigenetic diets rich in bioactive compoundssuch as sulforaphane, genistein, Epigallocatechin gallate(EGCG), resveratrol, and vitamin Ccan beneficially modulate sperm epigenomes and protect against environmentally induced abnormalities [104, 105]

Of all registered trials, 68 (5.6%) have published results in peer-reviewed journals (Supplementary Table 1)

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Notably, traditional compounds used for treating other diseases should be reevaluated to determine whether they work in tumors expressing mutant p53