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A 2024 review in BioImpacts synthesizing the topical GHK-Cu evidence concluded that the peptide has consistent anti-wrinkle and skin-rejuvenating activity in human studies, though formulation and delivery remain ongoing challenges [5]

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The rodent synaptogenesis finding is therefore better treated as unsettled than as established, and the human question remains entirely open

One of the primary advantages of tripeptides lies in their ability to interact with specific cellular receptors and signaling pathways, enabling them to influence diverse aspects of the wound healing cascade [54]

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