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Colonic epithelial cell-specific knockdown of the FASN gene significantly inhibits Mucin 2 (MUC2) palmitoylation, leading to impaired mucus secretion, abnormal intestinal barrier permeability, and flora-immunity imbalance, which eventually may induce colitis and systemic inflammatory response (145)
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doi: 10.1016/j.ejcb.2024.151450, 17
