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GLP-1 receptor agonists such as liraglutide, semaglutide, and dulaglutide have shown significant reductions in major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke, primarily in people with established cardiovascular disease or high cardiovascular risk
It has shown potential for supporting the management of chronic gastrointestinal conditions, such as inflammatory bowel diseases (IBD), including ulcerative colitis (UC)
Cardiovascular Effects and Antihypertensive Combinations Triple agonists lower blood pressure through three additive mechanisms: weight loss, natriuresis (GLP-1R-mediated), and a direct vascular effect of glucagon receptor agonism on vascular smooth muscle
Less than 5% of patients transplanted for ALD at our center had graft dysfunction due to relapse after LT, suggesting overall good graft outcomes even in those that unfortunately relapsed
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