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Efficacy and safety of canagliflozin as add-on therapy to a glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus: A 52-week, open-label, phase IV study

These effects seem to be mediated by GLUT4, which triggers PI3K/PKB, and glucose, which inhibits the LKB1/AMPK pathway

& Szostak, J

Patients with elevated fasting insulin or polycystic ovary syndrome often require medication that addresses both appetite suppression and insulin sensitivitytwo areas where tirzepatide shows clinical advantage

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