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Biochemistry 48 , 61666174 (2009)

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It activates two receptors simultaneously: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 19 million people

Tirzepatide, by contrast, activates both the GLP-1 receptor and the GIP receptora dual-action approach that engages two separate appetite-regulation systems in the brain and gut