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Risk Stratification & Contraindications Patient safety must guide the initiation of GLP-1 therapy, and therapy should be withheld if contraindications are present: Absolute Contraindications: Personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Cautionary History: Previous pancreatitis or gastroparesis 5

Rami Bailony, an obesity specialist and CEO of Enara, who was not involved in the research, told MNT that his initial reaction was one of cautious interest as it is important to interpret the results in a broader context

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