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S5 show that GLP-1RA were associated with lower risks as compared with placebo (16% lower risk), DPP-4 inhibitors (15% lower risk) and SGLT-2 inhibitors (10% lower risk), but the difference was statistically significant as compared with placebo only

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In addition, SULTR1;2 has been proposed to act as sensor of sulfur status of plants (Zhang et al., 2014), but more evidence is necessary to dissect the mechanism of such sensing

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However, previous studies have not resolved certain questions: i) whether alterations in the identified proteins and metabolites are affected by eye drops, ii) how these changes in proteins and metabolites are affected by glaucoma phenotype, and iii) whether normal-tension glaucoma shows protein and metabolite changes in the same way as POAG

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