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2-HG has been demonstrated to inhibit histone demethylation, specifically the Jumonji family histone lysine demethylase KDM4C, thereby impairing the expression of genes important in normal cellular differentiation (27)
Archived from the original on August 21, 2022
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Appetite stimulation is a plausible on-target effect because GHSR-1a is also the receptor for ghrelin, a hunger-signaling hormone
Your doctor will typically monitor your response through clinical improvement and blood tests such as full blood count, rather than rechecking B12 levels after starting injections
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