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Additional evaluations may include transcriptional and proteomic changes in metabolic signaling pathways, glucose transport assays (including markers associated with GLUT4 in adipocytes or skeletal muscle), and lipid-related metrics such as intracellular lipid accumulation or gene expression associated with lipogenesis

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Methionine and cysteine residues are vulnerable to oxidation, especially under light or trace metal exposure (Manning et al., Pharm Res, 2010)