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Additionally, SGLT2is can be used in various therapeutic associations considering their overall efficacy and safety profile and the unique insulin-independent mechanism of action

10.1002/cbf.1245

*Correspondence: Frederik Flindt Kreiner, [email protected] This article was submitted to Clinical and Translational Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Metformin remains the first-line oral agent for most adults with type 2 diabetes, unless contraindicated

Additionally, as the first CVD to develop in patients with diabetes is often heart failure rather than myocardial infarction [1], it is becoming clear that the pathology of diabetes itself causes heart failure through direct effects on cardiomyocytes and other myocardial cell types

Expect a recurrence of GI side effects during the first 2 to 4 weeks on the new agent, even if you tolerated dulaglutide well