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The SURMOUNT-1 phase 3 double-blind, randomized, controlled trial in adults with obesity without diabetes received once weekly tirzepatide (5, 10, or 15 mg) versus placebo for 72 weeks [9]
And does the delivery method change the equation
This no-observed-effect level (NOEL) indicates the minimum exposure needed to trigger a detectable physiological or biochemical change
Qi et al., 2021), however, to our knowledge this had not previously been shown in the cerebrovasculature
We conducted a search of the literature on 20 November 2023 via Ovid SP of PubMed/MEDLINE, Embase, Cochrane CENTRAL and PsycInfo databases from inception, updated with serial manual searches until 13 July 2024
pmid:16421451 49
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