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Early data suggest greater efficacy than dual agonists

Here's what the current long-term data shows, drawn from TRIUMPH-4 and TRIUMPH-1: Source: TRIUMPH-4 (N=445, 12mg dose, 68 weeks) and TRIUMPH-1 (N=2,339, 80 weeks + 104-week extension)

Clinical studies have shown that higher doses can produce greater weight loss outcomes, but not every patient requires the maximum dose

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Once activated, active pro-inflammatory cytokines (e.g., IL-18 and IL-1b) are produced, which in turn induce cell death through various mechanisms, thus maintaining intestinal homeostasis

Data used in the gene set enrichment analysis are available in Supplementary Table 11 (ref