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It is found in large quantities in many cells in the body (1-10 millimoles/L)

Mechanisms include ATP sensitive K + channel closure, facilitation of VDCCs opening, inhibiting membrane repolarization via Kv channels and Ca 2+ -induced Ca 2+ release from cytoplasmic storage sites 9,10,11,12,13,14

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These are powerful mechanisms, but they both operate on the "input" side of the energy balance equation

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Para el manejo del peso, la tirzepatida (Zepbound) est indicada en adultos con obesidad (IMC 30 kg/m) o sobrepeso (IMC 27 kg/m) con al menos una condicin relacionada con el peso, como complemento a una dieta reducida en caloras y mayor actividad fsica