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British Journal of Pharmacology, 179 , 727742
A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction
Shukla AP et al
However, certain conditions such as poor diet, lifestyle, and environmental factors such as pollution and exposure to radiation may increase free radicals in the body
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